Sunday, October 25, 2009

Natural Killer Cells


Natural Killer Cells:-
Researchers from Brown University and McGill University discovered that natural killer or natural killer cells, help to prevent T cells from over-respond when it hits the virus. This balance and help to prevent T-cells, which are usually in the immune system from causing damage.
Natural killer or natural killer cells, are part of the innate immune system. And produces a healthy body to respond to them early in the infection. They kill infected cells and activate specific virus.

Found natural killer cells is more important for the body than previously thought. Researchers from Brown University and McGill University, we now know that the cells also help to maintain the T-cells - key players in cell immunity - from over-responding. Such a balance and help T cells to maintain their role in the immune response to adapt, rather than becoming a very revitalization of many of causing harm.

This enables the discovery, published in the September issue of the Journal of Experimental Medicine, one day be used to help in the treatment of patients who suffer from immune system is weak. Managing the production of natural killer cells could help stabilize the immune system of people who suffer from HIV or prevent patients from the rejection of bone marrow or organ transplantation.

Results establish the importance of understanding how to preserve the surrounding natural killer cells, it can be lost, "said senior author Christine Byron], a professor of medical science at Brown University. Seung-Hwan Lee, Postdoctoral Fellow at the Byron]'s lab, is first author on the paper.

"The action reflects the two important aspects of Nagorno-Karabakh, a cell biologist, and the first piece is understanding how to preserve the natural killer cells, instead of losing them," said Byron], and Esther Elizabeth Brintzenhoff professor in the Department of Microbiology and Molecular Immunology. "The second is that if you can keep them around, they have an important function of organizational adaptation to reduce immune response. If you do not have them through the challenges a long time, to adapt to your immune system response that can go unregulated and lead to death."

Scientists know that natural killer cells to the effects of anti-microbial. But new research focus on factors that help to keep the surrounding natural killer cells. Through the study of mice, researchers determined that the ability to keep the surrounding natural killer cells depends on whether they have a special type of activated receptors to encourage the spread of weapons.

Once activated, NK cells expanded help to drive the production of cytokine known as interleukin-10, and the effects of immunoregulation and control of infections. (Cytokines are protein molecules that helps regulate the immune system) On the other hand, IL (10 helps to dampen T-cell response. Overabundance of T-cells in this case can be harmful to the body and lead to death.

Byron] said it was important to know that can help make natural killer cells proliferate, and an important milestone for help in maintaining the body when needed.

Such an understanding is crucial, she said, to help patients who suffer from a weak immune system who may not be able to withstand natural killer cells alone.

Said Byron] research emphasizes the need for balance in the immune system, with the right combination between North Korea and T-cells to supplement innate immunity and adaptive in the body.

"Do you want the right balance," she said. "This can help to create the right balance."

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