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Peyronie's Disease Treatment:
Introduction:
Peyronie's disease is characterized by a plaque or hard lump, that forms inside the penis. Painting, flat-panel of the scar tissue, develops in the upper or lower side of the penis into the thick membrane called the Tunica albuginea, which envelopes tissue dysfunction. Painting begins as a localized inflammation and progression to hardening of the scar. This painting is not related to the painting that can develop in the arteries.

Cases of Peyronie's disease range from mild to severe. Symptoms may develop slowly or appear overnight. In severe cases, and reduces the hardening of plaque flexibility, causing pain and forcing the penis to bend or arc during erection. In many cases, and reduces the pain with the passage of time, but the bend in the penis may remain a problem, which makes it difficult to sexual contact. Sexual problems that can lead to destabilization of the couple's relationship of physical, emotional, and can reduce the man and self-esteem. In a small percentage of men with milder form of the disease may resolve without causing inflammation of the great suffering or permanent bending.

Painting itself is benign, or noncancerous. It is not a tumor. Peyronie's disease is not contagious and not known to be caused by any disease transmission.

Plate on the deck of the shaft, which is the most common, and causes the penis to bend upward, a commemorative plaque on the underside lead to curve downward. In some cases, the plaque develops on both top and bottom, leading to indentation and shortening of the penis. In some cases, pain, bending, and emotional distress prohibit sexual intercourse.

The cross-section of the penis (left) displays the internal cavity, which runs along the penis and is divided into two rooms - Totals cavernosa by a vertical connecting tissue known as the barrier. Scientists believe that during the trauma, such as bending, bleeding may occur in the moment of the seizure of the barrier to the Tunica albuginea lining the wall of the room (center). Results scar bleeding in the disk, or plate, which is characteristic of Peyronie's disease. Painting reduces the flexibility on one side of the penis during erection, leading to curvature (right).

Prevalence estimates of Peyronie's disease, ranging from less than 1 percent to 23 percent.1 recent study in Germany found Peyronie's disease 3.2 percent of men between 30 and 80 years of age.2 Although the disease occurs mostly in middle age, and younger and older men and can be developed. Stiffness about 30 percent of men with Peyronie's disease tissue development in other parts of the body, such as the hand or foot. A common example is a condition known as Dupuytren's contracture hand. In some cases, Peyronie's disease runs in families, suggesting that genetic factors may make men susceptible to the disease.

The French surgeon Francois de la Biruni, first described Peyronie's disease in 1743. The problem was noted in print in early 1687. Early writers classified as a form of disability, which is now called erectile dysfunction). Peyronie's disease can be associated with impotence and the inability to achieve or maintain an erection firm enough for sexual intercourse.

However, experts now recognize ED as only one factor associated with the disease, one of the factors that are not always present.

1 Wessells H, Joyce GF, Wise M, Wilt TJ. Erectile dysfunction and Peyronie's disease. In: Litwin MS, Saigal CS, editors. Urology in the United States. Ministry of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Diabetes and diseases of the digestive system and kidneys. Washington, DC: United States Government Printing Office, 2007; the National Institutes of Health Publication No. 07-5512:483-530.

2 Sommer F, Schwarzer U, Wassmer G, Bloch W, Brown said, Klotz T, Engelmann U. The epidemiology of Peyronie's disease. International Journal of Disability Research. 2002; 14:379-383.

How can the development of Peyronie's disease?

Many researchers believe this painting of Peyronie's disease develops after the trauma, such as beatings or bending, which causes localized bleeding inside the penis. Chambers, known as aggregates cavernosa run the length of the penis. And connecting tissue, and called for the barrier, which runs between the two chambers and attaches at the top and bottom of the tunic albuginea.

If the penis is bumped or bent, an area where the barrier attached to the tunic albuginea may extend beyond the limit, injuring and albuginea tunic and rupturing small blood vessels. As a result of aging, has been reduced flexibility near the point of attachment in the barrier increases the chances of injury. In addition, it can also be a form of barrier is damaged and difficult, and fibrous tissue, called fibrosis.

Tunica albuginea and have many dimensions, and the flow of blood through those little layers. Therefore, the inflammation can be trapped between the layers for several months. During that time, inflammatory cells may release substances that cause excessive fibrosis and reduce flexibility. This process eventually forms of chronic plaque with excessive amounts of scar tissue, causing calcification and loss of flexibility in the Bekaa, and distorts the penis.

While the shock might explain some cases of Peyronie's disease, it does not explain why most cases develop slowly and not with the traumatic event and clear. Nor does it explain why some cases, the solution or why similar conditions such as Breast reduction does not seem to result from severe trauma.

Some researchers suggest that theorizing Peyronie's disease, there may be an autoimmune disorder.

How is the evaluation of Peyronie's disease?.

And doctors can usually diagnose Peyronie's disease on the basis of physical examination. And can be panel felt when the penis is limp. A full assessment, however, may require examination during erection to determine the severity of deformity. This may be an incentive for the erection by injecting medicine into the penis or through self-motivation. Some patients may eliminate the need to induce an erection in the doctor's office to take Polaroid pictures or digital in the home. The examination may include an ultrasound of the penis to identify the location (s), and calcification in the painting. And ultrasound can also be used to evaluate blood flow into and out of the penis if there is concern about not being able to have an erection.

How is the treatment of Peyronie's disease?.

Men with Peyronie's disease usually seek medical attention because of painful erections, deformity of the penis, or difficulty in sexual intercourse. Because the cause of Peyronie's disease and development are not well understood, a doctor specializing in the treatment of this disease an experimental fashion, that is, they continue to impose and methods that seem to help. The goal of treatment is to restore and maintain the ability to have intercourse. And provide education about the disease and its course often is all that is required. Did not show strong evidence that any treatment other than surgery is effective at the global level. Experts usually recommend surgery only in cases of long-term stable disease and deformity prevents intercourse.

Because the course of Peyronie's disease is different in each patient, and because some patients without treatment and improve the experience and medical experts suggest waiting 1 year or more before he underwent surgery. During this wait, patients often are willing to undergo the treatment effectiveness was not proven.
Medical treatments:

Researchers conducted small-scale studies in which men with Peyronie's disease who were given vitamin (e) an oral report improvements. However, there are no controlled studies have established the effectiveness of vitamin therapy (e). A similar critical success was attributed to the potassium aminobenzoate (Potaba). Other oral medications that have been used include colchicine, tamoxifen, and pentoxifylline. Again, no controlled studies of these drugs.

Researchers also tried to inject chemicals such as verapamil, collagenase, steroids, and alpha interferon - 2b directly into the plaques. Verapamil and alpha interferon - 2b seems to reduce the curvature of the penis. Other agent by injection, collagenase, subject to clinical trial results are not yet available. Stimulants, such as cortisone, have produced unwanted side effects, such as atrophy or death of healthy tissues. Another involves the intervention of Iontophoresis, the use of a painless current of electricity to deliver verapamil or some other agent under the skin in the painting.

Radiation therapy, in which high-energy rays are aimed at the painting, has also been used. Such as some chemotherapy drugs or radiation seems to reduce pain, but it has no effect on the painting itself, and can cause unwanted side-effects, such as erectile dysfunction. Although many of the agents and methods used indicates that there is no proven treatment, new insights into the healing process may one day lead to more effective treatments.
Surgery:
Three operations for Peyronie's disease has achieved some success. One procedure involves the removal or pieces of plaque and to link a piece of skin, race, or materials made from animal organs. This method may correct the penis and restore some lost along the Peyronie's disease. However, some patients may experience numbness of the penis, and the loss of erectile function.

The second procedure, called the fold, including removal of an insolvent or a piece of Tunica albuginea of the penis against the side of the painting, which eliminates the impact of the curve. This method is less likely to cause numbness or inability to have an erection, but can not be restored or a belt of the length of the penis.

A third option is to plant a surgical device that increases the hardness of the penis. In some cases, planting alone will not correct the penis adequately. If the implant alone does not correct the penis, and implantation is combined with one of the two other surgical procedures.

Most types of surgery produce positive results. But because complications can occur, and because many of the effects of Peyronie's disease, for example, shortening of the penis are not usually corrected by surgery, most doctors prefer to conduct surgical operations only a small number of men with severe curvature enough to prevent intercourse.


Remember points to:

* Peyronie's disease is characterized by a plaque or hard lump, that forms inside the penis.
* In severe cases, and reduces the hardening of plaque flexibility, causing pain and forcing the penis to bend or arc during erection.
* This painting itself is benign, or noncancerous. It is not a tumor. Peyronie's disease is not contagious and not known to be caused by any disease transmission.
* For the treatment of Peyronie's disease include medicines by mouth, injections, and surgery.
* Medical experts suggest waiting 1 year or more before attempting to correct Peyronie's disease surgically.